The entourage effect

Entourage effect, a Hemp synergy

As science and research advance more on the cannabis field, researchers are discovering and bringing to the light more effects, properties and possible uses for the compounds found in the Cannabis plant.

Currently, a field of main interest is the possible effects of the phytocannabinoids when working combined with other plant molecules instead of on its own. It’s known as the entourage effect.

Given the Cannabis plant’s complexity and the stigmatization created around it, we’re only just starting to scratch the surface when it comes to hemp knowledge.

So let’s jump onto the matter and find out what we know.

The beginning

The hemp was first associated with the word synergy in 1998 when the Professors Raphael Mechoulam and Shimon Ben-Shabat introduced the “entourage effect” theory.

Many people know Professor Mechoulam as the “father of cannabis” for his many discoveries and research around the cannabis plant. One of his most notable findings is the THC molecule. Possibly Dr Mechoulam could win a Nobel Prize for his work and contributions to cannabis research, time will tell us.


Synergy is the interaction of elements that, when combined, produce a total effect that is greater than the sum of the individual parts.

For example, think of 1+1=3.

You can find synergies everywhere in nature. Hydrogen and oxygen combine to form water; bees create colonies or wolf hunt in packs. 

Similarly, imagine a group of musicians playing music. Each instrument playing on its own can be meaningless; however, it can become a beautiful harmony if you assemble them. The list of synergies in the world is never-ending!

So, coming back to our synergy, the entourage effect assumes that combining the cannabis plant naturally occurring compounds: phytocannabinoids, terpenes and flavonoids, is more effective than if taken on their own. So, for example, consuming a CBD isolated would be less effective than if taken combined with more plant elements.

Scientific evidence

Most researchers relatively well accept the entourage effect’s existence, but the reasons behind its exact working mechanics still unknown. They keep working with the thousands of possible different combinations of cannabinoids, terpenes and other compounds found in the hemp plant.

Overall, people’s experiences show that CBD is likely more effective when taken with other phytocannabinoids, terpenes, and flavonoids of the plant. 

We believe that all plant compounds work together interacting and improving overall effect but, as previous discussed, isn’t fully established how this occurs.


Like most things in nature, the cannabis plant is highly complex, and research is just starting even more when it comes to the entourage effect.

Even though VoN believes in the entourage effect, belief isn’t science. As supporters, our oils contain a blend of phytocannabinoids, terpenes and flavonoids

More studies are needed in this field to be able to understand the mechanisms of hemp interactions completely. Currently, most evidence is just anecdotal. Lucky enough, everyday new data is coming across to understand better this marvellous plant.

So what do you think about the entourage effect? Is it better combined or isolated? What is your experience? Leave us a comment.

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